The Arizona Diamondbacks visit the Colorado Rockies on Tuesday, September 22, 2026. Arizona comes in with a solid 82-74 record, showing they’ve had a competitive season. Colorado, on the other hand, is struggling at 57-99. This clear gap in team performance is reflected in the betting odds.
Arizona is favored on the moneyline at -198, meaning you’d need to bet $198 to win $100 on them outright. The Rockies are the underdog at +163, offering a bigger payout if they pull off the upset. The spread is set at 1.5 runs, with Arizona giving -1.5 at -126 odds. This means Arizona needs to win by at least two runs for a bet on them to pay off. Betting on Colorado at +1.5 with +104 odds means they can either win or lose by just one run, and your bet still wins.
The total runs line is 11.0, with the over at -105 and the under at -115. These prices suggest a fairly even expectation on scoring, but slightly favoring the under because of the better payout.
Given Arizona’s much better record and the odds favoring them both on the moneyline and spread, they look like the safer bet. However, the spread price of -126 shows the market expects a competitive game, so consider if you want to risk a bit more for Arizona to cover the run line or take the Rockies with the +1.5 cushion. The total at 11 runs is another angle, but with no further info, it’s a toss-up.