Cleveland Indians vs Boston Red Sox

Tuesday, September 22, 2026 6:45 PM ET Game 17080467
Cleveland Indians
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Cleveland Indians
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Boston Red Sox
Boston Red Sox
Game Analysis

Tuesday’s game between the Cleveland Indians and Boston Red Sox looks like a close contest based on the records and odds. Cleveland is 81-75, while Boston holds a slight edge at 84-72. The Red Sox are at home, which usually gives them a small advantage.

Looking at the spread, Cleveland is +1.5 at -205. That means you’d need to bet $205 to win $100 if you take Cleveland to either win outright or lose by just one run. On the other side, Boston is -1.5 at +168, so a $100 bet could win $168 if the Red Sox win by two or more runs. The high juice on Cleveland’s spread suggests the sportsbook thinks Boston is the favorite but expects a close game.

The moneyline shows Cleveland at +109 and Boston at -131. This means a $100 bet on Cleveland nets $109 if they win outright, while you must bet $131 on Boston to win $100. The odds here confirm Boston as the favorite but not overwhelmingly so.

The total is set at 6.5 runs, with the over at -125 and the under at +104. The odds slightly favor the under, meaning the market expects a moderately low-scoring game.

In summary, Boston is the favorite at home but not by a wide margin. The spread and moneyline suggest a tight game. Expect pitching to play a big role, and the under on 6.5 runs looks like a reasonable option if you believe both teams will keep scoring in check.

Analysis updated September 22, 2026 at 6:00 AM
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