The Houston Astros visit the Seattle Mariners on Wednesday, September 23, 2026. Both teams are coming in with losing records—Houston at 78-79 and Seattle at 73-84. This game looks like a chance for Houston to push back above .500, while Seattle tries to finish the season strong.
Looking at the odds, the Mariners are slight favorites at home. They have a moneyline of -149, meaning you’d need to bet $149 to win $100 on Seattle straight up. The Astros are underdogs at +124, so a $100 bet on Houston pays $124 if they pull off the win. This suggests the market sees Seattle as the more likely winner, but not by a huge margin.
The run line (spread) is set at 1.5 runs. Houston is +1.5 at -171, so they’re favored to lose by fewer than two runs or win outright. Seattle is -1.5 at +141, meaning they need to win by two or more runs for that bet to pay off. The odds show that the sportsbook expects a close game, but leans toward Seattle winning comfortably.
The total runs line is 8.0, with a slight edge on the under at -115 versus the over at -105. This indicates a modest expectation for a lower-scoring game.
Overall, Seattle has the slight edge at home, but Houston’s odds to cover the +1.5 run line look attractive given the close matchup. The total suggests a game with some pitching control rather than a slugfest.