Louisville Cardinals vs Mississippi Rebels

Sunday, September 6, 2026 7:30 PM ET Game 17080161
Louisville Cardinals
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Louisville Cardinals
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Mississippi Rebels
Mississippi Rebels
Game Analysis

The Louisville Cardinals head to Oxford to face the Mississippi Rebels in a Sunday matchup. The Rebels are favored by 7 points, with a line at -105, meaning you’d need to bet $105 to win $100 on them covering the spread. Louisville is the underdog at +7 with -115 odds, so a $115 bet would win $100 if they lose by less than 7 or win outright.

Looking at the moneyline, Mississippi is a strong favorite at -270. That means you’d bet $270 to win $100 on the Rebels straight up. Louisville’s moneyline at +220 offers a nice payout for a road upset; a $100 bet wins $220 if Louisville wins the game.

The total points line sits at 55.5, with the over slightly more expensive at -108 and the under at -112. This suggests the market expects a moderately high-scoring game but leans just a bit toward fewer points.

In summary, the Rebels are clearly seen as the stronger team, favored both to win and cover by a touchdown. Louisville, as the underdog, offers value if you think they can keep it close or pull an upset. The total points line indicates a competitive game with a fair amount of scoring, but not a shootout. Your choice depends on whether you believe Mississippi can dominate or Louisville can keep pace. The odds reflect a solid home favorite vs. a respectable visitor, making this an intriguing early-season test.

Analysis updated September 2, 2026 at 6:04 AM
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