Wake Forest Demon Deacons vs Louisville Cardinals

Saturday, September 26, 2026 12:00 PM ET Game 17080559
Wake Forest Demon Deacons
Away
Wake Forest Demon Deacons
VS
Home
Louisville Cardinals
Louisville Cardinals
Game Analysis

Wake Forest and Louisville both come into this game with identical 2-1 records, setting the stage for a competitive matchup. Louisville is favored by 13.5 points at home, which means oddsmakers see them as a strong favorite. The negative number on the home spread (-112) means you’d have to bet $112 to win $100, while the away spread (+108) offers slightly better value on Wake Forest covering the large number.

Looking at the moneylines, Louisville is a heavy favorite at -550. This means you’d need to bet $550 to win $100 on Louisville outright. Wake Forest’s moneyline sits at +410, so a $100 bet would pay $410 if they pull off the upset. This big gap suggests bookmakers expect Louisville to win comfortably.

The total points line is set at 57.5, with the under priced slightly better (-112) than the over (-108). This implies a fairly balanced view on scoring, but a slight lean toward the game staying under that total.

In summary, Louisville is clearly the favorite and expected to win by two touchdowns or more. But the high spread means Wake Forest could still keep things close for bettors chasing points. The total around 57.5 points suggests a moderately scoring game. Bettors should weigh the risk of Louisville covering versus the potential payout on Wake Forest plus the points or moneyline.

Analysis updated September 25, 2026 at 6:01 AM
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