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SF

Arizona Cardinals vs San Francisco 49ers 9/21/25 NFL Free Pick

The upcoming NFL game between the Arizona Cardinals and the San Francisco 49ers is set to be an exciting clash between two undefeated teams. Both teams are entering the game with a two-game winning streak, making this matchup even more intriguing.

The Arizona Cardinals have been on a roll, sitting at the second position in the standings with a perfect 2-0 record. Their offense has been potent, averaging 23.5 points per game while allowing 17.5 points against. Led by quarterback Kyler Murray, the Cardinals have shown great chemistry and playmaking ability on the field.

On the other hand, the San Francisco 49ers, currently at the top of the standings, have also displayed strong performances in their two wins. With an offense that averages 21.5 points per game and a defense that allows 17 points against, the 49ers have proven to be a well-rounded team.

In terms of power ratings, the Cardinals hold a slight edge over the 49ers with a power rating of 255.00 compared to the 49ers' 220.00. This indicates that the Cardinals have been slightly more efficient in their gameplay, reflected in their higher points differential of 6.00 compared to the 49ers' 4.50.

Looking at the game odds, the 49ers are favored to win by 2.0 points, with odds of -115 for the home team and -105 for the Cardinals. The money line also slightly favors the 49ers at -130, indicating that oddsmakers see them as the slightly stronger team in this matchup. The over/under for total points scored is set at 45.0, suggesting a relatively low-scoring game.

When analyzing this game, it's essential to consider the strengths and weaknesses of both teams. The Cardinals have a dynamic offense led by Murray, while the 49ers boast a solid defense that can create turnovers. The key to victory for each team will be capitalizing on their strengths while minimizing mistakes.

In conclusion, this game between the Arizona Cardinals and the San Francisco 49ers promises to be a close and competitive battle. With both teams undefeated and on a two-game winning streak, it's difficult to predict the outcome with certainty. However, based on the current standings, power ratings, and odds, the 49ers have a slight advantage heading into this matchup. Fans can expect an intense and thrilling game as these two talented teams face off on the gridiron.

The ProCappers predicted final score is for the Arizona Cardinals to beat the home team San Francisco 49ers 24-22