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ARI

San Francisco 49ers vs Arizona Cardinals 11/16/25 NFL Free Pick

Alright folks, let's dive into the matchup between the San Francisco 49ers and the Arizona Cardinals. Both teams are coming off losses in their last games, so they'll be hungry to bounce back and secure a much-needed win.

The San Francisco 49ers currently sit at the 3rd position in the standings with 6 wins and 4 losses. They have been fairly consistent this season, with a balanced home record of 2-2 and a solid away record of 4-2. However, their recent loss may have dented their confidence a bit. The 49ers have scored 220 points while conceding 230, resulting in a slight negative points differential of -1.00.

On the other side, the Arizona Cardinals are placed 4th in the standings with 3 wins and 6 losses. They have struggled more at home with a 1-3 record but have been slightly better on the road with a 2-3 record. The Cardinals have scored 202 points and allowed 215 points, leading to a points differential of -1.44. Like the 49ers, they are looking to turn their fortunes around after their recent loss.

In terms of power ratings, the San Francisco 49ers hold a rating of -55.58 with a win percentage of 60%, while the Arizona Cardinals have a rating of -84.06 with a win percentage of 33%. These ratings give us a glimpse of the teams' overall performance and their chances of success in the upcoming game.

When it comes to the odds for this game, the 49ers are favored by 3.5 points on the road, with the Cardinals getting 3.5 points at home. The moneyline reflects the 49ers as favorites at -185, while the Cardinals are the underdogs at +160. The over/under is set at 48.5 points, indicating a potentially close and high-scoring game.

Considering all the stats, recent performances, and odds, this game promises to be a competitive battle between two teams looking to get back on the winning track. The 49ers have a slight edge based on their higher power rating and better overall record, but the Cardinals shouldn't be underestimated, especially when playing at home.

So, buckle up and get ready for an exciting showdown between the 49ers and the Cardinals as they clash on the gridiron in what could be a crucial game for both teams in their quest for playoff contention. Get your snacks ready and enjoy the game!

The predicted final score is for the Arizona Cardinals beating the visiting San Francisco 49ers 26-23.