Detroit Lions vs Buffalo Bills

Thursday, September 17, 2026 8:15 PM ET Game 17080294
Detroit Lions
Away
Detroit Lions
VS
Home
Buffalo Bills
Buffalo Bills
Game Analysis

The Buffalo Bills host the Detroit Lions in a Thursday night matchup, both teams coming in at 1-0. The Bills are favored by 5.5 points, with odds just slightly better on the home side (-105) compared to the Lions’ away spread (-115). This means the Bills are expected to win by about a touchdown, but the line isn’t too steep, indicating a potentially competitive game.

Looking at the moneyline, the Bills are priced at -238, making them the clear favorites to win straight up. A $238 bet on Buffalo would net you $100 if they win. Meanwhile, the Lions’ moneyline is +195, offering a nice payout for an underdog win. This suggests the market sees Buffalo as the stronger team but acknowledges Detroit could pull off an upset.

The total is set at 54.5 points, with the over priced at -120 and the under at +100. The slightly higher juice on the over means bettors are paying a bit more to take the combined score above 54.5. The under is a bit more favorable in terms of payout, which might appeal if you expect a tighter defensive game.

In summary, the Bills are favored but not by an overwhelming margin. Betting on Buffalo to cover the 5.5 points is close to even money, while an outright Lions upset offers a bigger reward. The total suggests a moderately high-scoring game, but the pricing leans slightly toward the underdog and the under.

Analysis updated September 17, 2026 at 6:00 AM
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