The Indianapolis Colts visit the Kansas City Chiefs on Sunday, September 20, 2026. The Colts enter this game with a 0-1 record, while the Chiefs are off to a perfect 1-0 start. This early season matchup features a spread of 6.5 points, with the Chiefs favored at home.
Looking at the odds, the Chiefs are priced at -285 on the moneyline, meaning a bettor would need to wager $285 to win $100 on a Chiefs outright victory. The Colts, as underdogs, offer a moneyline of +230, so a $100 bet would pay $230 if they pull off the upset. The spread suggests the Chiefs are expected to win by about a touchdown.
The Colts are getting points (+6.5), so bettors taking them on the spread win if the Colts lose by 6 or fewer points or win the game outright. The Chiefs need to win by 7 or more for those backing the home team on the spread to cash.
The total is set at 46.5 points, with even odds on the over and under at -110. This means bettors can wager on whether the combined score will be over or under 46.5 points, with a slight commission charged by the sportsbook.
In sum, the Chiefs are favored but not overwhelmingly so. The Colts are a decent underdog, offering value especially if they keep the game close. The moderate total suggests a game that could be competitive with a balanced scoring outlook. Bettors should weigh the Chiefs’ home advantage and early momentum against the Colts’ potential to cover the spread.