Seattle Seahawks vs Arizona Cardinals

Sunday, September 20, 2026 4:25 PM ET Game 17080433
Seattle Seahawks
Away
Seattle Seahawks
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Arizona Cardinals
Arizona Cardinals
Game Analysis

The Seattle Seahawks and Arizona Cardinals both enter this Week 2 matchup with perfect 1-0 records, setting the stage for an intriguing early-season battle. The betting lines favor Seattle, who are listed as 3.5-point road favorites at -120 odds. This means a bettor must risk $120 to win $100 on Seattle covering the spread. The Cardinals, as 3.5-point home underdogs, offer even money at +100, making them a tempting option for those who believe the home team can keep it close or pull off the upset.

Seattle’s moneyline sits at -218, indicating they are the clear favorite to win outright. Bettors would need to wager $218 just to win $100 backing the Seahawks straight up. Conversely, Arizona’s moneyline is +180, offering a higher payout for a Cardinals victory, reflecting their underdog status.

The total points line is set at 40.5, with the over priced at -115 and the under slightly better at -105. This suggests a moderate expectation for scoring, with a small edge on the under. Given both teams are undefeated and likely motivated early in the season, this total could be a key area to watch.

Overall, the line shows respect for Seattle but also offers value on Arizona as home underdogs. The spread and moneyline reflect a competitive game with Seattle favored but not overwhelmingly so. Bettors should consider these factors carefully when making their picks.

Analysis updated September 18, 2026 at 6:04 AM
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