Detroit Lions vs Arizona Cardinals

Sunday, October 11, 2026 4:25 PM ET Game 17080958
Detroit Lions
Away
Detroit Lions
VS
Home
Arizona Cardinals
Arizona Cardinals
Game Analysis

The Detroit Lions come into this game with a 2-2 record, while the Arizona Cardinals are sitting at 1-3. The Lions are favored on the road by 5.5 points, with odds of -108 on the spread. This means you’d need to bet $108 to win $100 if you take Detroit to cover. The Cardinals, as underdogs at home, have +5.5 points available at slightly better odds, -112.

Looking at the moneyline, the Lions are priced at -258, making them the clear favorites to win straight up. You’d need to risk $258 to win $100 on Detroit. The Cardinals are at +210, meaning a $100 bet would pay $210 if Arizona pulls off the upset.

The total is set at 54.5 points, with the over slightly less expensive at -115 compared to the under at -105. This suggests the sportsbook expects a moderately high-scoring game but is slightly leaning toward the under.

Given the Lions' better record and the odds, the market views them as the stronger team. The 5.5-point spread is somewhat sizable for an away team, indicating confidence in Detroit’s ability to win comfortably. Meanwhile, the Cardinals get a decent cushion with the points and a good payout on the moneyline if you believe they can surprise.

If you expect a competitive game with moderately high scoring, the total near 55 points is a key number to watch. The spread and moneyline favor Detroit, but the Cardinals offer value if you think they can keep it close or win outright.

Analysis updated October 10, 2026 at 9:05 PM
Want the Expert Picks?
Unlock premium picks from every ProCappers expert handicapper.
View Memberships