The Denver Broncos visit the Arizona Cardinals on Sunday, October 25, 2026. Denver comes in with a solid 4-2 record, while Arizona sits at 2-4. This gap in performance is reflected in the betting odds.
Denver is favored by 4.5 points, meaning they need to win by at least 5 points to cover the spread. The -110 price on both sides of the spread means you’d bet $110 to win $100, a standard juice for sportsbooks. The Broncos are also the moneyline favorite at -230, so a $230 bet would net $100 if Denver wins outright. Conversely, the Cardinals are underdogs at +190, offering a bigger payout if they pull off the upset.
The total points line is set at 43.5, with the over at -112 and the under at -108. This suggests the game could be moderately scoring. The odds slightly favor the under, but the difference is minimal, signaling a balanced expectation for scoring.
Given Denver’s better record and favored status, the smart play might lean toward the Broncos covering the 4.5-point spread. However, Arizona at +190 on the moneyline could appeal to those looking for value on an underdog. The total points line is close, so consider your comfort with game pace if betting over or under.
In short, Denver looks like the stronger team, but the spread and odds allow for multiple angles depending on your risk tolerance.